Journal of Liver Cancer

Soon Ho Um

2 Articles

Clinical Significance of the Up-To-Seven Score for the Assessment of the Tumor Stage in Patients with Hepatocellular Carcinoma: Chang Ho Jung, Yeon Seok Seo, Jae Min Lee, Seok Bae Yoon, Tae Jung Yun, Sun Young Yim, Hyong gin An, Soon Ho Um, Chang Duck Kim, Ho Sang Ryu; Journal of the Korean Liver Cancer Study Group. 2014;14(1):14-22. Published online March 31, 2014; DOI: https://doi.org/10.17998/jlc.14.1.14

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Abstract PDF: Background/Aim
s: Up-to-seven criteria was proven to be useful for predicting prognosis after liver transplantation in patients with hepatocellular carcinoma (HCC). The aim of this study was to evaluate that up-to-seven score could be useful method for prediction of prognosis in patients with HCC who did not undergo liver transplantation.
Methods
Between January 2006 and December 2008, 216 HCC patients without vascular invasion, lymph node and distant metastasis were analyzed retrospectively. We investigated the prognostic impact of laboratory findings, clinical characteristics, modified UICC T stage, and up-to-seven score in HCC. The survival analyses were performed using Kaplan-Meier method and Cox-regression analysis.
Results
Two-hundred sixteen patients with HCC were included. Age was 60.1±11.3 years and 74.5% were male. Chronic hepatitis B was the most common cause of liver disease (60.6%). T stage was T1, T2, and T3 in 36 (16.7%), 118 (54.6%), and 62 (28.7%) patients, respectively. Up-to-even score was 5.5±4.0 and it was <3 (UTS 1), ≥3 and ≤7 (UTS 2), and >7 (UTS 3) in 36 (16.7%), 133 (61.6%), and 47 (21.8%) patients, respectively. The 10 (8.5%) patients of T2 stage were classified into UTS 3 and 25 (40.3%) patients of T3 stage were classified into UTS 2. The prognosis was significantly different in patients with T2 or T3 according to their UTS. Multivariate analysis showed that Child-Pugh score and UTS were significantly associated factors with survival.
Conclusions
Up-to-seven score was useful to predict prognosis and to evaluate tumor stage in patients without vascular invasion, lymph node and distant metastasis.

Hepatic Failure after Chemotherapy in Patient with HBV-related HCC: Report of 1 Case: Sang Kyun Yu, Hwang Rae Chun, Chang Won Baeck, Soon Ho Um; Journal of the Korean Liver Cancer Study Group. 2005;5(1):45-48. Published online June 30, 2005

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Abstract PDF: Hepatitis B virus (HBV) reactivation is a well described complication in cancer patitient who receive cytotoxic chemotherapy and may result in varying degree of liver damage. Liver damage due to HBV exacerbation is a 2-stage process. The initial stage occurs during intense cytotoxic therapy and is characterized by enhancing viral replication, as reflected by increases in serum levels of HBV DNA, HBeAg, which presumably result in widespread infection of hepatocytes. The second stage is related to restoration of immune function following withdrawl of cytotoxic therapy, which cause rapid immune-mediated destruction of infected hepatocyte. Clinically, this may lead to hepatitis, hepatic failure, and even death. We report a case of hepatic failure after chemotherapy in patient with HBV-related hepatocelluar carcinoma.

Soon Ho UM

2 Articles

Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma with Arterioportal Shunt : A Report of One Case: Sang Kyun Yu, Soon Ho Um, Cheol Young Kim, Sung Bum Cho, Nam Hee Won; Journal of the Korean Liver Cancer Study Group. 2004;4(1):29-32. Published online June 30, 2004

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Abstract PDF: Transcatheter arterial chemoembolization(TACE) is an effective treatment method in the management of patients with inoperable hepatocellular carcinoma. The effectiveness of TACE, however, is decreased, when arterioportal shunt is present, since embolic and chemotherapeutic agents are diverted from the tumor to the normal parenchyma through branches of the portal vein. In such case, TACE may not only be ineffective, but also cause hepatic infarction followed by hepatic failure. We report a case of hepatocellular carcinoma with arterioportal shunt, successfully treated by TACE.

A case of Hypovascular Hepatocellular Carcinoma: Hwan Hoon Chung , Yoon Hwan Kim, Yong Sun Kim, Soon Ho UM, Nam Hee Won; Journal of the Korean Liver Cancer Study Group. 2001;1(1):64-67. Published online June 30, 2001

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Abstract PDF: A 54 year-old-male patient was referred to our hospital, because a hepatic mass had been found on US at a local clinic. He was a heavy drinker, but he has never experienced any significant diseases so far. Anti-HBs Ab was positive and HBsAg and anti-HCV Ab were negative. AFP level was normal. US showed a 2.3 cm sized hyperechoic nodule in the lateral segment of left lobe of the liver. Attenuation of the nodule was lower than that of normal hepatic parenchyma on triphasic CT scan. No definite hypervasculairity was seen on the angiogram, CTHA and single level dynamic CTHA. sono-guided needle biopsy was done for the lesion, and it was confirmed to be hepatocellular carcinoma, Edmondson grade 1. Left lateral segmentectomy was performed and the patient was dischaged 11 days after the operation. There has been no evidence of recurrence during 1 year-follow-up